Cancer of unknown primary (CUP)

The Royal Marsden provides a diagnostic, treatment and follow-up service for cancers of unknown primary (i.e. patients with a positive diagnosis of cancer but whose doctors can't be sure where the cancer started).

Cancer of unknown primary (CUP) is becoming less common due to improved diagnostic imaging and pathology to identify the primary cancer site. However, as a tertiary centre, The Royal Marsden still reviews a relatively large numbers of patients with this diagnosis.

All patients are discussed in the weekly CUP multidisciplinary team meeting which has representatives from medical and clinical oncology, radiology, pathology, gastroenterology, interventional radiology and palliative care.

The service participates in clinical research enrolling patients where possible into the national CUP1 trial.