Promising signs in early trial for personalised cancer vaccines
Dr Lopez, who presented the results at this year’s virtual AACR conference (American Association for Cancer Research), added: “We were able to generate tumour-specific immune responses in the majority of evaluable patients, using a personalised cancer vaccine approach in combination with immune checkpoint blockade. It is like our overall low clinical response rate is due to the advanced disease many of patients had, and the large number of treatments they had already received.”
Researchers are looking to expand this area of investigation, to understand potential for patients with earlier stage cancers, and with a larger patient population.
The study was funded by Genentech and BioNTech. Limitations of the study include a small sample size. Furthermore, due to the single-arm nature, the study results cannot be directly compared with atezolizumab monotherapy.
The Oak Foundation Drug Development Unit is a joint unit of The Royal Marsden and The Institute of Cancer Research, London. The unit treats close to 300 patients a year on Phase I trials, making it one of the largest facilities of its kind in the world. The Unit was funded thanks to a donation by The Oak Foundation to The Royal Marsden Cancer Charity, and since opening has continued to have a global impact with novel drug treatments.
Supported by The Royal Marsden Cancer Charity
Supporters of The Royal Marsden Cancer Charity have enabled the Charity to help improve the patient experience for children and their families. The Charity contributed £16 million to the cost of the Oak Centre for Children and Young People when it was built and have since funded the creation of break-out spaces such as the Pandora parents’ lounge and outdoor play areas.
The Charity continues to fund a number of different services within the centre including a team of play specialists who use their understanding of child development, therapeutic play activities and distraction techniques to help young patients prepare for and cope with painful or invasive procedures, scans and treatment and to ensure the service runs smoothly. The Charity also supports the pain management team, who work closely with the physiotherapists and psychologists to help children and young people improve their pain management and find ways of coping.