- the hormonal aspects of breast cancer
- the assessment of biomarkers
- the clinical development of aromatase inhibitors
Professor Mitch Dowsett is Head of the Centre for Molecular Pathology, Head of the Ralph Lauren Centre for Breast Cancer Research, and Head of the joint Academic Department of Biochemistry at The Royal Marsden and The Institute of Cancer Research. He also holds the posts of Professor of Biochemical Endocrinology at The Royal Marsden, and Professor of Translational Research at the Breast Cancer Now Research Centre at the ICR.
He was awarded the William McGuire Memorial Lectureship in 2007 and has been a Senior Investigator of the NIHR since 2009. He recently became only the third recipient from the UK of the Brinker Award for Scientific Distinction in Clinical Research.
Professor Dowsett’s research focuses almost exclusively on breast cancer and predominantly on hormonal aspects of the disease and biomarkers of response. He has been closely involved with the clinical development of aromatase inhibitors and the establishment of Ki67 as an intermediate marker of treatment benefit. His work has focused mainly on the assessment of biomarkers in large Phase III clinical trials. He has written widely on this, including on the general potential and limitation of such study.