Coronavirus (COVID-19): visiting The Royal Marsden suspended

Due to the increasing numbers of cases of coronavirus across the UK, we have suspended all visiting to The Royal Marsden apart from specific circumstances. Read here for more information.

Haemato-oncology clinical trials

Clinical trials are an important part of improving treatment for patients.

Academic and commercial trials are run through the Haemato-oncology Unit. Trials that are currently recruiting are listed below under each disease category.

Please email us for more information about our haemato-oncology clinical trials.

Acute leukaemias

Acute myeloid leukaemia (AML) trials

  • IDH1 inhibitor study for adults with AML with IDH1 mutation, either relapsed or refractory to conventional treatment or for those unsuitable for conventional treatment at presentation.
  • Trial of MDM2 antagonist in combination with intensive chemotherapy for relapsed/refractory AML in fit adults
  • AML19 for untreated patients aged 18-60 years with AML. Looking at one vs two doses of gemtuzumab ozogamicin with standard chemotherapy
  • AML18 for untreated patients aged over 60 years with AML. Looking at one vs two doses of gemtuzumab ozogamicin with standard chemotherapy

Acute lymphoblastic leukaemia (ALL) trials

  • UKALL2011 trial for young adults aged 18-24 years with untreated ALL, looking at different doses of steroids and high dose methotrexate
  • MEK inhibitor trial for relapsed/refractory acute lymphoblastic leukaemia with RAS-pathway mutations in adults.

Chronic lymphoid leukaemias

  • Randomised clinical trial comparing R-FC to R-Ibrutinib in treatment naïve CLL patients with intact TP53
  • Randomised clinical trial comparing Ibrutinib to Acalabrutinib in patients with previously treated CLL with ATM or TP53 loss


  • A dose-finding study of single agent idelalisib in the treatment of double-refractory follicular lymphoma
  • A clinical trial of ibrutinib, lenalidomide and rituximab in patients with relapsed/refractory DLBCL

Myelodysplastic syndromes and other myeloid disorders

For patients with low blood counts of uncertain cause we have a gene sequencing study to test whether any genes are mutated.


  • An immunotherapy trial for patients with relapsed myeloma, combining daratumumab with a checkpoint inhibitor. Patients who do not respond to this combination go on to receive pomalidomide and dexamethasone in addition
  • A dose-finding study of a next generation thalidomide analogue
  • MUK7 – a randomised study comparing pomalidomide and dexamethasone with pomalidomide, dexamethasone and cyclophosphamide in patients with relapsed myeloma
  • MUK8 – a randomised study comparing cyclophosphamide and dexamethasone with ixazomib, cyclophosphamide and dexamethasone in patients with relapsed myeloma
  • iTIMM – an imaging study for newly diagnosed patients with myeloma that requires therapy which will include a stem cell transplant. Patients undergo a PET/CT scan and whole body diffusion weighted MRI at diagnosis, and then a further MRI after initial therapy and again after transplant