Our research summaries

The Royal Marsden regularly conducts and publishes clinical research in medical and scientific journals.

These research papers are long and written in language suitable for a scientific audience, so we are also providing summaries aimed at members of the public and health professionals who are not specialists in cancer.

Research summaries 

• A Phase I trial of ONX-0801 exploring once weekly and alternate week dosing regimens in patients with solid tumours by Professor Udai Banerji
• Neoadjuvant Chemotherapy and Radiotherapy before Mastectomy & DIEP Reconstruction (PRADA) by Ms Fiona MacNeill
• NBT – National Brain Tumour Study (GLIOGENE) by Professor Richard Houlston
• FCLL –A Genetic Study of Chronic Lymphocytic Leukaemia and Other Lymphoproliferative Disorders by Professor Richard Houlston
• Exploratory study of the molecular profile of thyroid cancer by Dr Kate Newbold
• Genetics of Multiple Cancers Study (GeMCaS) by Professor Clare Turnbull
• The UK Genetics of Testicular Cancer Study by Professor Clare Turnbull
• Evaluation of new Magnetic Resonance Techniques by Professor Nandita deSouza
• The effect of an aromatherapy intervention on sleep in the ICU by Dr Natalie Pattison
• Family Needs in Critical Care by Professor Theresa Wiseman
• Using the Phase of Illness tool in paediatric palliative care by Dr Anna-Karenia Anderson
• CORIOLIS by Dr Liam Wesh
• Diffusion weighted Imaging study in cancer of the ovary by Professor De Souza
• The Fibre Study - RCT= Efficacy of fibre in pelvic radiotherapy patients by Dr Andreyev
• Dihydro-testosterone (FDHT) PET/CT Imaging in patients with Progressive Prostate Cancer by Professor Oyen
• Imaging Hypoxia in Head & Neck Cancer by Dr Kate Newbold
• Assessing Treatment Response of Breast Cancer Using Multimodal Functional Imaging by Professor De Souza
• Caphosol in management of H&N radiotherapy-related mucositis by Dr Kate Newbold
• Imaging in Clinical Trials - a questionnaire study to assess impact of imaging regimes on patient participation by Professor De Souza
• Investigation of lactate measured using magnetic resonance spectroscopy as a biomarker of tumour response (lactate imaging) by Professor De Souza
• Evaluation of canADVICE M-health system to support cancer patients receiving oral anti-cancer drugs - Proof of concept by Dr Jillian Noble
• Molecular analysis of tumour cells in pleural and ascitic fluid from patients with ovarian and other solid cancers by Professor Stan Kaye
• Preoperative Imaging of Retroperitoneal Sarcomas by Dr Christina Messiou
• An exploration of how parents manage their child's cancer-related pain at home by Theresa Wiseman
• Tissue collection for genome sequencing, establishing cell lines and tumour xenografts, from patients with salivary gland carcinoma by Professor Kevin Harrington
• TAX-TORC: A phase 1 multi-centre trial of the combination of AZD2014 (dual mTORC1 and mTORC2 inhibitor) and weekly Paclitaxel in patients with solid tumours by Professor Udai Banerji
• The use of 3D surface imaging in the objective assessment of breast conserving therapy by Miss Jennifer Rusby
• Case control study to evaluate the impact of radiotherapy on patients undergoing DIEP flap breast reconstruction, by Miss Jennifer Rusby
• An Exploratory Study of Pre-treatment Staging and Post-treatment Assessment in Malignant Lymphoma by Whole Body Diffusion-weighted MR Imaging (WB-DWI) and ADC-mapping in comparison to 18 FDG PET/CT by Sue Chua. 
• Feasibility study testing multi-panel coding and non-coding transcriptional responses as an indicator of individualised responses to radiation effects in radiation therapy patients (RTGene) by Navita Somaiah
• Pilot study to develop predictive biomarkers for drugs targeting the ALK and p53 pathways for children with neuroblastoma by Professor Louis Chesler
• Biomarkers of sensitivity to fraction size in curative radiotherapy – Radiobiology research involving persons with Li-Fraumeni Syndrome by Navita Somaiah 
• Mutational analysis in gastrointestinal stromal tumors (GIST): prognostic value in terms of relapse free survival and response and response duration on treatment with imatinib and /or sunitinib by Professor Ian Judson 
• A pilot study to assess the role of competencies of clinical research nurses within a specialist cancer hospital by Ann Muls
• Biomarkers of sensitivity to fraction size in curative radiotherapy - collection and banking of normal tissue by Dr Navita Somaiah
• PeriOpErative Target Therapy for Individualised Care-2: A Feasibility Study by Professor Ian Smith
• Testing whether the Microsoft Kinect system can detect patients holding their breath during radiotherapy by Dr Anna Kirby
• Functional Imaging in Radical Chemo-radiotherapy for Head & Neck Cancer by Dr Kate Newbold 
• Risk of chronic adverse effects in patients undergoing radical radiotherapy for breast and prostate cancers by Professor John Yarnold
• Report on the patients referred to the Lymph node diagnostic clinic by Professor David Cunningham
• Comparing MRI and CT bowel cancer scans to see which helps doctors see disease progression more accurately by Professor Gina Brown
• Randomised comparison of conventional histological processing of colorectal cancers with MRI guided specimen dissection for histology by Professor Gina Brown
• A study looking at a new treatment plan for locally advanced cancer of the pancreas (PERU) by Dr Ian Chau
• MRS Studies in Oncology by Professor Nandita de Souza
• Testing biopsy samples for genetic mutations in small-cell lung cancer by Dr Mary O'Brien
• The effectiveness of acupuncture for the relief of breathlessness in lung cancer by Dr Mary O'Brien
• The HeartSpare Study (Stage 1) - Optimisation and Individualisation of Heart-Sparing Breast Radiotherapy Techniques by Dr Anna Kirby
• Expectations and experiences of participation in phase I anti-cancer clinical drug trials by Dr Natalie Pattison
• Development & Evaluation of endocavity magnetic resonance techniques by Professor Nandita de Souza
• Functional MR in the assessment of metastatic bone disease - version 1 by Professor Nandita de Souza
• The validation of two inpatient adult nutrition screening tools in cancer care – a prospective study by Dr Clare Shaw 
• How experiencing advanced cancer affects male patients' perceptions of masculinity by Dr Natalie Pattison
• Testing whether reflexology is as effective as aromatherapy in relieving cancer symptoms by Dr Clare Shaw
• Educating senior cancer nurses in Motivational Interviewing and Solution-Focused approaches: A case study by Dr Natalie Pattison